Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372689 | 0.94 | DGAT1 (0.31) | DGAT1SMN1; SMN2 | |
| SCHEMBL26696628 | 0.70 | DGAT1 (0.39) | DGAT1SMN1; SMN2EPHX1 | |
| SCHEMBL20054644 | 0.70 | DGAT1 (0.39) | DGAT1SMN1; SMN2EPHX1 | |
| SCHEMBL9066294 | 0.70 | DGAT1 (0.39) | DGAT1 | |
| SCHEMBL15233815 | 0.68 | DGAT1 (0.36) | DGAT1SMN1; SMN2EPHX1 | |
| SCHEMBL22739189 | 0.67 | EPHX1 (0.37) | DGAT1SMN1; SMN2EPHX1 | |
| SCHEMBL29990419 | 0.67 | DGAT1 (0.37) | DGAT1SMN1; SMN2EPHX1 | |
| Hydrochloric Acid SCHEMBL14889550 | 0.65 | EPHX1 (0.36) | DGAT1SMN1; SMN2EPHX1 | |
| SCHEMBL6120239 | 0.64 | L3MBTL1 (0.34) | DGAT1 | |
| SCHEMBL16732111 | 0.64 | EPHX1 (0.38) | DGAT1SMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017383-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-28 | — | — | EP | disclosed |
| EP-1017383-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2000-07-12 | — | — | EP | disclosed |
| US-6087373-A | A SERINE PROTEASE INHIBITOR FOR PREVENTING OR TREATING UNSTABLE ANGINA, REFRACTORY ANGINA, MYOCARDIAL INFARCTION, TRANSIENT ISCHEMIC ATTACKS, ATRIAL FIBRILLATION, THROMBOTIC STROKE, EMBOLIC STROKE, DEEP VEIN THROMBOSIS | MERCK & CO., INC. (US) | 2000-07-11 | — | — | US | disclosed |
| WO-1999015169-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1999-04-01 | — | — | WO | disclosed |