Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | SLC25A1 | P53007 | 2/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.53 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.53 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.53 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30515749 | 0.92 | MEN1 (0.70) | KMT2AMEN1POLBCASP3SENP8 | |
| SCHEMBL24215474 | 0.92 | MEN1 (0.70) | KMT2AMEN1POLBCASP3SENP8 | |
| SCHEMBL5059972 | 0.89 | KMT2A (0.57) | KMT2AMEN1POLBSLC25A1MAPT | |
| SCHEMBL7451598 | 0.85 | POLB (0.67) | KMT2AMEN1POLBCASP3SENP8 | |
| SCHEMBL9749511 | 0.85 | FFAR4 (0.71) | KMT2AMEN1SLC25A1MAPTLMNA | |
| SCHEMBL30515748 | 0.82 | KMT2A (0.70) | KMT2AMEN1POLBCASP3SENP8 | |
| SCHEMBL9997594 | 0.79 | SLC25A1 (0.65) | KMT2AMEN1SLC25A1MAPTHSD17B10 | |
| SCHEMBL7450548 | 0.79 | POLB (0.59) | KMT2AMEN1POLBCASP3SENP8 | |
| SCHEMBL3619380 | 0.79 | SLC25A1 (0.67) | KMT2AMEN1SLC25A1MAPTLMNA | |
| SCHEMBL7366821 | 0.79 | AKR1C3 (0.67) | KMT2AMEN1AKR1C3MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001074786-A1 | HETEROBIARYLSULPHONAMIDES AND THEIR USE AS PDE 7 INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-10-11 | — | — | WO | disclosed |