Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828182 | 0.79 | KMT2A (0.79) | POLBKMT2ASMN1; SMN2PKMAPP | |
| SCHEMBL7373350 | 0.79 | POLB (0.54) | POLBKMT2ASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL7368133 | 0.76 | KMT2A (0.64) | POLBKMT2ASMN1; SMN2PKML3MBTL1 | |
| SCHEMBL9828111 | 0.75 | KMT2A (0.68) | POLBKMT2ASMN1; SMN2PKML3MBTL1 | |
| SCHEMBL9828399 | 0.73 | KMT2A (0.66) | POLBKMT2ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL9828492 | 0.73 | KMT2A (0.64) | POLBKMT2ASMN1; SMN2MAPK1PDE4B | |
| SCHEMBL9827887 | 0.72 | KMT2A (0.63) | POLBKMT2ASMN1; SMN2MAPK1PDE4B | |
| SCHEMBL7375489 | 0.72 | KMT2A (0.55) | POLBKMT2ASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL9827437 | 0.71 | POLB (0.62) | POLBKMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7372988 | 0.71 | KMT2A (0.52) | POLBKMT2ASMN1; SMN2OPRM1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706517-B1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL IND LTD (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0706517-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001343-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1995-01-12 | — | — | WO | disclosed |