SCHEMBL7373350

SCHEMBL7373350

COc1ccc(CNc2cn[nH]c(=O)c2Cl)cc1OCC(=O)NCc1cccnc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.54
KMT2A Q03164 2/20 0.54
NOTUM Q6P988 1/20 0.49
ATM Q13315 1/20 0.48
CYP1A2 P05177 2/20 0.47
CYP3A4 P08684 2/20 0.47
CYP2C9 P11712 1/20 0.47
ALDH1A1 P00352 3/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
USP2 O75604 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
DHODH Q02127 1/20 0.47
MAPK1 P28482 1/20 0.46
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
HPGD P15428 2/20 0.44
HSD17B10 Q99714 1/20 0.44
PKM P14618 1/20 0.44
TSHR P16473 1/20 0.44
BLM P54132 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7368133 0.83 KMT2A (0.64) POLBKMT2ACYP3A4CYP2C9ALDH1A1
SCHEMBL9828182 0.81 KMT2A (0.79) POLBKMT2AALDH1A1L3MBTL1SMN1; SMN2
SCHEMBL9828111 0.80 KMT2A (0.68) POLBKMT2AALDH1A1L3MBTL1SMN1; SMN2
SCHEMBL7373347 0.79 POLB (0.52) POLBKMT2AALDH1A1L3MBTL1USP2
SCHEMBL9828399 0.78 KMT2A (0.66) POLBKMT2AALDH1A1NPSR1SMN1; SMN2
SCHEMBL9828492 0.78 KMT2A (0.64) POLBKMT2ACYP1A2CYP3A4ALDH1A1
SCHEMBL7372988 0.77 KMT2A (0.52) POLBKMT2ACYP3A4CYP2C9ALDH1A1
SCHEMBL9827887 0.77 KMT2A (0.63) POLBKMT2ACYP1A2CYP3A4ALDH1A1
SCHEMBL7375489 0.76 KMT2A (0.55) POLBKMT2AALDH1A1L3MBTL1USP2
SCHEMBL9827437 0.76 POLB (0.62) POLBKMT2AALDH1A1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5929074-A VSODILATOR, ANTIALLERGIC AND ANTIPLATELET AGENTS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-27 US disclosed
EP-0706517-B1 PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY NISSAN CHEMICAL IND LTD (JP) 1998-10-21 EP disclosed
EP-0706517-A1 PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1996-04-17 EP disclosed
WO-1995001343-A1 PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1995-01-12 WO disclosed