Sugi Predict

Sugi Predict / Compounds / SCHEMBL73734

SCHEMBL73734

SCHEMBL73734

CC(C)(C)c1cc(N=C=O)no1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 2/20 0.46
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ NPC1 O15118 4/20 0.36
▸ RAB9A P51151 4/20 0.36
▸ MAPK14 Q16539 2/20 0.35
▸ RAPGEF3 O95398 4/20 0.34
▸ HPGD P15428 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ PKM P14618 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19461803 0.83 EGFR (0.33) EGFR
SCHEMBL24571147 0.81 L3MBTL1 (0.31) EGFR
SCHEMBL6392097 0.81 EGFR (0.42) EGFRMEN1KMT2ANPC1RAB9A
SCHEMBL13234661 0.79 EGFR (0.49) EGFRMEN1KMT2ANPC1RAB9A
SCHEMBL590632 0.75 — —
SCHEMBL11035557 0.72 SMN1; SMN2 (0.36) NPC1RAB9AALDH1A1MAPK1SMN1; SMN2
SCHEMBL4160572 0.68 EGFR (0.50) EGFRMEN1KMT2ANPC1RAB9A
SCHEMBL11284931 0.68 RAB9A (0.40) MEN1KMT2ANPC1RAB9AHPGD
SCHEMBL21653364 0.67 KMT2A (0.47) EGFRMEN1KMT2ANPC1RAB9A
SCHEMBL668043 0.67 ALDH1A1 (0.39) MAPK14ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 166 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11384076-B2 Synthesis, pharmacology and use of new and selective FMS-like tyrosine kinase 3 (FLT3) FLT3 inhibitors UNIVERSITÄT REGENSBURG (DE) 2022-07-12 — — US claimed
CN-108912599-B Filter film obtained by compounding nitrile rubber and phenolic resin 长春峰泰汽车胶业有限公司 2020-12-25 — — CN claimed
CN-108912599-A The filter film that a kind of nitrile rubber and phenolic resin compound 长春峰泰汽车胶业有限公司 2018-11-30 — — CN claimed
EP-4637926-A1 SYNTHESIS, PHARMACOLOGY AND USE OF NEW WATER-SOLUBLE AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) INHIBITORS Universität Regensburg (DE) 2025-10-29 — — EP disclosed
WO-2024132278-A1 SYNTHESIS, PHARMACOLOGY AND USE OF NEW WATER-SOLUBLE AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) INHIBITORS UNIVERSITÄT REGENSBURG (DE) 2024-06-27 — — WO disclosed
WO-2024132278-A1 SYNTHESIS, PHARMACOLOGY AND USE OF NEW WATER-SOLUBLE AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) INHIBITORS UNIVERSITÄT REGENSBURG (DE) 2024-06-27 — — WO disclosed
EP-4389223-A1 SYNTHESIS, PHARMACOLOGY AND USE OF NEW WATER-SOLUBLE AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) INHIBITORS Universität Regensburg (DE) 2024-06-26 — — EP disclosed
EP-4389223-A1 SYNTHESIS, PHARMACOLOGY AND USE OF NEW WATER-SOLUBLE AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) INHIBITORS Universität Regensburg (DE) 2024-06-26 — — EP disclosed
CN-116410203-B Compound with TRK and drug-resistant mutation inhibition activity and application thereof 四川大学 2024-06-25 — — CN disclosed
EP-3668867-B1 SYNTHESIS, PHARMACOLOGY AND USE OF NEW AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) FLT3 INHIBITORS UNIV REGENSBURG (DE) 2023-10-04 — — EP disclosed
CN-116410203-A Compound with TRK and drug-resistant mutation inhibition activity and application thereof 四川大学 2023-07-11 — — CN disclosed
US-4394510-A Process for preparing an isoxazolylurea ELI LILLY AND COMPANY (US) 1983-07-19 — — US disclosed
EP-0057550-A1 Process for preparing an isoxazolylurea ELI LILLY AND COMPANY (US) 1982-08-11 — — EP disclosed
US-4336056-A 1,1-DIMETHYL-3-(5-TERT-BUTYL-3-ISOOXAZOLYL)UREA ELI LILLY AND COMPANY (US) 1982-06-22 — — US disclosed
US-4302239-A 3-(5- or 3-Substituted-5- or 3-isoxazolyl)-1-allyl or alkyl-4-substituted-5-substituted or unsubstituted-2-imidazolidinones for controlling weeds PPG INDUSTRIES, INC. (US) 1981-11-24 — — US disclosed
EP-0034456-A1 3-(Substituted 3- or 5-isoxazolyl)-1-4-, or 5-substituted-2-imidazolidinones, methods for their preparation, compositions containing them and their use as herbicides PPG INDUSTRIES, INC. (US) 1981-08-26 — — EP disclosed
US-4268679-A 3-[5- or 3-Substituted-5- or 3-isoxazolyl]-1-allyl or alkyl-4-substituted-5-substituted or unsubstituted-2-imidazolidinones PPG INDUSTRIES, INC. (US) 1981-05-19 — — US disclosed
US-4116671-A HERBICIDES SHIONOGI & CO., LTD. (JP) 1978-09-26 — — US disclosed
US-4111680-A HERBICIDAL COMPOSITIONS CONTAINING 3-ISOXAZOLYLUREA DERIVATIVES SHIONOGI & CO., LTD. (JP) 1978-09-05 — — US disclosed
US-4062861-A HERBICIDE SHIONOGI & CO., LTD. (JA) 1977-12-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11384076-B2 Synthesis, pharmacology and use of new and selective FMS-like tyrosine kinase 3 (FLT3) FLT3 inhibitors FLT3, CSF3R, ABL1 EGFR 51/4885MEN1 1639/4885KMT2A 742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.