Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367472 | 0.88 | KDM4E (0.39) | MAPK14AURKA | |
| SCHEMBL7296061 | 0.86 | IGF1R (0.51) | IGF1RMAPK1MAPK14MAPK3ADORA1 | |
| SCHEMBL7364009 | 0.84 | LMNA (0.37) | PTGS2ABCB1ABCC1 | |
| SCHEMBL5673928 | 0.83 | MAPK14 (0.40) | MAPK14ADORA1AURKAPTGDR2PTGS2 | |
| SCHEMBL6818747 | 0.79 | AURKA (0.39) | IGF1RMAPK1MAPK14MAPK3AURKA | |
| SCHEMBL7373757 | 0.78 | PTGDR2 (0.37) | IGF1RMAPK14ADORA1AURKAPTGDR2 | |
| SCHEMBL5671102 | 0.78 | MAPK14 (0.50) | MAPK14ADORA1PTGS2EGFRRAF1 | |
| SCHEMBL6821442 | 0.74 | HTR6 (0.37) | IGF1RMAPK1MAPK14AURKAPTGS2 | |
| SCHEMBL6822095 | 0.74 | MAPK14 (0.39) | IGF1RMAPK14ADORA1AURKAPTGDR2 | |
| SCHEMBL7369957 | 0.73 | PDE3A (0.48) | IGF1RMAPK1MAPK14MAPK3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |