Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 4/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395677 | 0.88 | PDE3A (0.42) | PDE3APDE5ACYP1A2PDE3BMAPK14 | |
| SCHEMBL7401220 | 0.87 | PDE3A (0.41) | PDE3APDE5ACYP1A2IGF1RPDE3B | |
| SCHEMBL7367727 | 0.85 | LMNA (0.53) | PDE3APDE5ACYP1A2PDE3BMAPK1 | |
| SCHEMBL5810385 | 0.85 | PDE3A (0.65) | PDE3APDE5ACYP1A2IGF1RMAPK1 | |
| SCHEMBL7363841 | 0.84 | PDE3A (0.45) | PDE3APDE5ACYP1A2PDE3BPIM1 | |
| SCHEMBL7366330 | 0.83 | PDE3A (0.40) | PDE3APDE5ACYP1A2PDE3BMAPK14 | |
| SCHEMBL7399130 | 0.82 | PDE3A (0.45) | PDE3APDE5ACYP1A2PDE3BMAPK1 | |
| SCHEMBL5670985 | 0.80 | ADORA2A (0.41) | IGF1RMAPK14ADORA1PIM1PIM2 | |
| SCHEMBL7373031 | 0.79 | ADORA1 (0.48) | IGF1RMAPK1MAPK14ADORA1EGFR | |
| SCHEMBL7369589 | 0.78 | PDE3A (0.39) | PDE3APDE5ACYP1A2PDE3BMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |