Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13430532 | 0.85 | TGFBR1 (0.58) | PDE10ATGFBR1ATMTGFBR2MAPK14 | |
| SCHEMBL9524502 | 0.83 | PDE10A (0.50) | PDE10ATGFBR1ATMTGFBR2NPC1 | |
| SCHEMBL27309763 | 0.83 | ATM (0.61) | PDE10ATGFBR1ATMTGFBR2NPC1 | |
| SCHEMBL27310627 | 0.81 | PDE10A (0.46) | PDE10ATGFBR1ATMTGFBR2NPC1 | |
| SCHEMBL9524516 | 0.77 | PDE10A (0.41) | PDE10ATGFBR1ATMTGFBR2NPC1 | |
| SCHEMBL9196852 | 0.71 | ATM (0.67) | PDE10ATGFBR1ATMTGFBR2NPC1 | |
| SCHEMBL9199906 | 0.70 | PDE10A (0.57) | PDE10ATGFBR1ATMTGFBR2NPC1 | |
| SCHEMBL9701112 | 0.69 | PDE10A (0.57) | PDE10ATGFBR1ATMTGFBR2NPC1 | |
| SCHEMBL11482604 | 0.69 | MAPT (0.59) | PDE10ATGFBR1ATMTGFBR2NPC1 | |
| SCHEMBL17767553 | 0.68 | TGFBR1 (0.59) | PDE10ATGFBR1TGFBR2MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990015534-A1 | MONOKINE ACTIVITY INTERFERENCE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-27 | — | — | WO | disclosed |
| EP-0403251-A2 | Monokine activity interference | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |