Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.58 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 5/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27309763 | 0.86 | ATM (0.61) | TGFBR1TGFBR2PDE10AATMPSEN1 | |
| SCHEMBL9524502 | 0.86 | PDE10A (0.50) | TGFBR1TGFBR2PDE10AMAPK14MAPK13 | |
| SCHEMBL7374657 | 0.85 | PDE10A (0.47) | TGFBR1TGFBR2PDE10AMAPK14MAPK13 | |
| SCHEMBL27310627 | 0.84 | PDE10A (0.46) | TGFBR1TGFBR2PDE10AMAPK14MAPK13 | |
| SCHEMBL9436258 | 0.83 | TGFBR1 (0.69) | TGFBR1TGFBR2PDE10AMAPK14MAPK13 | |
| SCHEMBL7378515 | 0.82 | TGFBR1 (0.65) | TGFBR1TGFBR2PDE10AMAPK14MAPK13 | |
| SCHEMBL7343693 | 0.82 | TGFBR1 (0.65) | TGFBR1TGFBR2PDE10AMAPK14MAPK13 | |
| SCHEMBL17767553 | 0.82 | TGFBR1 (0.59) | TGFBR1TGFBR2PDE10AMAPK14MAPK13 | |
| SCHEMBL9524516 | 0.80 | PDE10A (0.41) | TGFBR1TGFBR2PDE10AATMPDE4D | |
| SCHEMBL9700043 | 0.79 | TGFBR1 (0.60) | TGFBR1TGFBR2PDE10AMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069436-A1 | IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT | Merckle (DE) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069436-A1 | IMIDAZOLE COMPOUNDS HAVING AN ANTIINFLAMMATORY EFFECT | MIF, TNF, IL1B | TGFBR1 680/4885TGFBR2 817/4885PDE10A 2639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.