Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7380544 | 0.89 | PLAU (0.55) | PLAUNAMPTHTTADAMTS4MMP2 | |
| SCHEMBL7049646 | 0.85 | PLAU (0.43) | PLAUMMP2MMP9MMP8MMP13 | |
| SCHEMBL6437337 | 0.83 | PLAU (0.45) | PLAUNAMPTHTTADAMTS4MMP2 | |
| SCHEMBL7363440 | 0.81 | POLB (0.40) | ADAMTS4MMP2MMP9 | |
| SCHEMBL7048344 | 0.80 | PLAU (0.42) | PLAUHTT | |
| SCHEMBL7366260 | 0.79 | PLAU (0.39) | PLAU | |
| SCHEMBL7375649 | 0.79 | NR1D1 (0.35) | PLAUMMP2MMP9MMP8MMP13 | |
| SCHEMBL7377977 | 0.79 | PLAU (0.36) | PLAUNAMPTHTTMMP2MMP9 | |
| SCHEMBL7050066 | 0.78 | PLAU (0.39) | PLAUHTT | |
| SCHEMBL7378343 | 0.78 | PDE4A (0.41) | PLAUNAMPTMMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |