Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.39 |
| ▸ | PLG | P00747 | 4/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374993 | 0.92 | PLAU (0.42) | PLAUPLGPLATALDH1A1KDM4E | |
| SCHEMBL7370338 | 0.87 | PLAU (0.34) | PLAUPLGPLATALDH1A1GAA | |
| SCHEMBL7375772 | 0.87 | PLAU (0.38) | PLAUPLGPLATALDH1A1KDM4E | |
| SCHEMBL7365021 | 0.87 | MMP2 (0.36) | PLAUPLGPLATL3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL7376139 | 0.86 | PLAU (0.51) | PLAUPLGPLATALDH1A1L3MBTL1 | |
| SCHEMBL7363440 | 0.85 | POLB (0.40) | PLGALDH1A1POLBF2MAPT | |
| SCHEMBL7050306 | 0.83 | PLAU (0.37) | PLAUPLGPLATALDH1A1KDM4E | |
| SCHEMBL7367638 | 0.81 | S1PR1 (0.40) | PLAUALDH1A1F2PDK1PDK2 | |
| Hydrochloric Acid SCHEMBL7588559 | 0.81 | PLG (0.52) | PLAUPLGPLAT | |
| SCHEMBL7370515 | 0.80 | PLAU (0.37) | PLAUALDH1A1PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |