Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 4/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.31 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19797901 | 0.82 | APOBEC3A (0.41) | APOBEC3AAPOBEC3GSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3054669 | 0.76 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL23716719 | 0.75 | APOBEC3A (0.41) | APOBEC3AAPOBEC3GSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL20360594 | 0.74 | KDM4E (0.49) | APOBEC3AAPOBEC3GSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23367000 | 0.74 | APOBEC3A (0.41) | APOBEC3AAPOBEC3GSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23716720 | 0.73 | APOBEC3A (0.40) | APOBEC3AAPOBEC3GSMN1; SMN2ALDH1A1CTDSP1 | |
| Hydrochloric Acid SCHEMBL23354063 | 0.73 | APOBEC3A (0.40) | APOBEC3AAPOBEC3GSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL25562761 | 0.72 | APOBEC3A (0.39) | APOBEC3AAPOBEC3GSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL25457959 | 0.72 | APOBEC3A (0.46) | APOBEC3AAPOBEC3GSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL15833426 | 0.71 | APOBEC3A (0.42) | APOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165500-A1 | AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE | Du Pont Pharmaceuticals Company (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059874-A1 | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |