Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 12/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | GNA15 | P30679 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377400 | 0.85 | MAPT (0.47) | F2F10AKR1C3TDP1ALDH1A1 | |
| SCHEMBL7373419 | 0.85 | ITGB3 (0.66) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7375119 | 0.83 | FFAR1 (0.47) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7450519 | 0.81 | PPARG (0.65) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7379804 | 0.81 | ITGB3 (0.55) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7375111 | 0.80 | ITGB3 (0.49) | ITGB3ITGA2BF2F10ITGB1 | |
| SCHEMBL7861970 | 0.79 | ITGB3 (0.76) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL4109710 | 0.78 | FFAR1 (0.53) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7520428 | 0.78 | PARP1 (0.42) | ITGB3ITGA2BF10ITGAVAKR1C3 | |
| SCHEMBL7379531 | 0.77 | ITGB3 (0.56) | ITGB3ITGA2BITGB1ITGAVITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-B1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-02-06 | — | — | EP | claimed |
| EP-1157985-A1 | Para- substituted phenylene derivatives and their use as integrin antagonists | G.D. SEARLE & CO. (US) | 2001-11-28 | — | — | EP | claimed |
| US-6251944-B1 | (VITRONECTIN RECEPTOR) INTEGRIN ANTAGONIST, USEFUL FOR TREATING ANGIOGENESIS, TUMOR GROWTH, TUMOR METASTASIS, OSTEOPOROSIS AND HUMORAL HYPERCALCEMIA OF MALIGNANCY | G. D. SEARLE & COMPANY | 2001-06-26 | — | — | US | claimed |
| EP-0891325-B1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-1157985-A1 | Para- substituted phenylene derivatives and their use as integrin antagonists | G.D. SEARLE & CO. (US) | 2001-11-28 | — | — | EP | disclosed |
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |