Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 10/20 | 0.42 |
| ▸ | NOS3 | P29474 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423582 | 0.81 | NOS2 (0.41) | NOS2NOS3 | |
| SCHEMBL7378051 | 0.81 | NOS2 (0.38) | NOS2NOS3 | |
| SCHEMBL7417662 | 0.81 | NOS2 (0.41) | NOS2NOS3 | |
| SCHEMBL7420397 | 0.81 | NOS2 (0.49) | NOS2NOS3 | |
| SCHEMBL7380703 | 0.80 | NOS3 (0.37) | NOS2NOS3MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL7383900 | 0.80 | NOS3 (0.40) | NOS2NOS3 | |
| SCHEMBL7422091 | 0.79 | NOS2 (0.36) | NOS2NOS3 | |
| SCHEMBL7563046 | 0.78 | NOS2 (0.38) | NOS2NOS3 | |
| SCHEMBL7593931 | 0.77 | NOS2 (0.40) | NOS2NOS3HPGD | |
| SCHEMBL7423018 | 0.76 | NOS3 (0.40) | NOS2NOS3NPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000073313-A1 | NEW TRICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2000-12-07 | — | — | WO | disclosed |