Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.55 |
| ▸ | KIT | P10721 | 4/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | PDE1A | P54750 | 2/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382397 | 0.96 | PDE3B (0.53) | PDE3BPDE3AKITSGK1PDE5A | |
| SCHEMBL7388786 | 0.88 | PDE3B (0.51) | PDE3BPDE3AKITSGK1PDE5A | |
| SCHEMBL7377905 | 0.83 | PDE3B (0.64) | PDE3BPDE3AKITBRD4HPGD | |
| SCHEMBL7382710 | 0.78 | PDE3B (0.55) | PDE3BPDE3AHPGDLMNAKDM4E | |
| SCHEMBL7387266 | 0.78 | MEN1 (0.59) | PDE3BPDE3AKITHPGDLMNA | |
| SCHEMBL7383419 | 0.77 | PDE3B (0.70) | PDE3BPDE3A | |
| SCHEMBL7375384 | 0.74 | PDE3B (0.55) | PDE3BPDE3AKITPDE5APDE1A | |
| SCHEMBL7386282 | 0.73 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL7382885 | 0.73 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL7384334 | 0.73 | PDE3B (0.64) | PDE3BPDE3AHPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963561-A | Phosphodiesterase inhibitors | STERLING DRUG INC. (US) | 1990-10-16 | — | — | US | claimed |
| US-5010086-A | Enzyme inhibitor for treating congestive heart failure or hypertension in mammals | STERLING DRUG INC. (US) | 1991-04-23 | — | — | US | disclosed |