Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6721386 | 0.91 | RAB9A (0.53) | LMNASMN1; SMN2RAB9ANPC1CASP3 | |
| SCHEMBL6728967 | 0.87 | RAB9A (0.54) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL6720727 | 0.86 | LMNA (0.54) | LMNASMN1; SMN2ALDH1A1L3MBTL1MAPT | |
| SCHEMBL7375900 | 0.86 | KMT2A (0.57) | LMNASMN1; SMN2RAB9ANPC1CASP3 | |
| SCHEMBL7378410 | 0.84 | RAB9A (0.45) | LMNASMN1; SMN2RAB9ANPC1CASP3 | |
| SCHEMBL6719835 | 0.80 | MAPT (0.49) | LMNASMN1; SMN2ALDH1A1L3MBTL1MAPT | |
| SCHEMBL7378406 | 0.78 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1L3MBTL1MAPT | |
| SCHEMBL6717182 | 0.76 | NPC1 (0.50) | LMNARAB9ANPC1ALDH1A1L3MBTL1 | |
| SCHEMBL7375546 | 0.75 | SIGMAR1 (0.57) | LMNASMN1; SMN2RAB9ANPC1CASP3 | |
| SCHEMBL8996663 | 0.73 | SIGMAR1 (0.56) | LMNAALDH1A1L3MBTL1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5190976-A | Neuroprotective | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND UNIVERSITY OF OREGON (US) | 1993-03-02 | — | — | US | disclosed |