Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | ITGAV | P06756 | 3/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376063 | 0.89 | KMT2A (0.43) | LMNAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL7379500 | 0.89 | ALDH1A1 (0.42) | LMNAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL7380612 | 0.87 | ITGB3 (0.43) | LMNAITGB3ITGA2BITGAVMAPT | |
| SCHEMBL7375578 | 0.86 | ALDH1A1 (0.41) | LMNAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL7375584 | 0.86 | ALDH1A1 (0.41) | LMNAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL7377895 | 0.84 | F10 (0.38) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7380572 | 0.82 | ITGB3 (0.40) | LMNAKMT2ASMN1; SMN2ALDH1A1ITGB3 | |
| SCHEMBL7380439 | 0.80 | ALDH1A1 (0.43) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7375593 | 0.80 | ALDH1A1 (0.42) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7466483 | 0.77 | NPC1 (0.45) | MEN1KMT2ASMN1; SMN2ALDH1A1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |