Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.41 |
| ▸ | REN | P00797 | 8/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335353 | 0.85 | REN (0.38) | HSD17B10CHRM1RENALDH1A1 | |
| SCHEMBL7337426 | 0.82 | REN (0.38) | HSD17B10CHRM1REN | |
| SCHEMBL7330557 | 0.78 | AVPR1A (0.38) | HSD17B10CHRM1REN | |
| SCHEMBL7332722 | 0.77 | LMNA (0.38) | RENL3MBTL1ALDH1A1 | |
| SCHEMBL7332084 | 0.77 | KMT2A (0.43) | RENALDH1A1 | |
| SCHEMBL9437543 | 0.76 | F2 (0.34) | HSD17B10L3MBTL1 | |
| SCHEMBL9437442 | 0.76 | CTSS (0.36) | RENUSP7 | |
| SCHEMBL7330563 | 0.75 | AVPR1A (0.36) | HSD17B10CHRM1RENALDH1A1 | |
| SCHEMBL9556729 | 0.75 | REN (0.44) | HSD17B10CHRM1RENLTA4H | |
| SCHEMBL7329117 | 0.75 | CTSS (0.34) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | claimed |
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| WO-1992022313-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |