Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5369129 | 0.78 | ROCK2 (0.46) | ROCK2PIM1PIM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL5203573 | 0.77 | F2 (0.57) | GAAKMT2A | |
| SCHEMBL5374688 | 0.75 | GAA (0.47) | ROCK2PIM1PIM3ALDH1A1GAA | |
| SCHEMBL5734925 | 0.73 | F2 (0.47) | ROCK2PIM1PIM3ALDH1A1GAA | |
| SCHEMBL30969220 | 0.73 | ESRRG (0.54) | ROCK2PIM1PIM3PLGPLAU | |
| SCHEMBL27725660 | 0.72 | RAPGEF4 (0.43) | KDM4EHPGDCHEK1KMT2APOLB | |
| SCHEMBL3717533 | 0.72 | CDK4 (0.41) | ALDH1A1KDM4EL3MBTL1HPGDKMT2A | |
| SCHEMBL29949827 | 0.71 | ROCK2 (0.52) | ROCK2PIM1PIM3LCKALDH1A1 | |
| SCHEMBL30098896 | 0.71 | AR (0.64) | ROCK2PIM1PIM3LCKALDH1A1 | |
| SCHEMBL8574795 | 0.71 | AR (0.64) | ROCK2PIM1PIM3LCKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | disclosed |