Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPN | P05981 | 2/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL28780664 | 0.79 | PLAU (0.48) | GAAALDH1A1PLAUKDM4EHSD17B10 | |
| SCHEMBL5369135 | 0.78 | CHEK1 (0.52) | CHEK1ALDH1A1HTTCHEK2 | |
| SCHEMBL5203581 | 0.77 | GAA (0.54) | CHEK1GAAALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL5374691 | 0.76 | GAA (0.47) | CHEK1GAAALDH1A1CHEK2 | |
| SCHEMBL5733402 | 0.76 | SLC6A2 (0.44) | CHEK1GAAMMP2MMP13CHEK2 | |
| SCHEMBL5733310 | 0.73 | GAA (0.44) | CHEK1GAAALDH1A1L3MBTL1KDM4E | |
| SCHEMBL21898452 | 0.73 | MAPT (0.51) | GAAALDH1A1L3MBTL1PKMST14 | |
| SCHEMBL29684111 | 0.72 | HRH3 (0.49) | L3MBTL1PLAUKDM4EHSD17B10POLB | |
| SCHEMBL1651087 | 0.72 | MMP2 (0.66) | ALDH1A1MMP2MMP13CYP2C19KDM4E | |
| SCHEMBL2940750 | 0.72 | HRH3 (0.49) | L3MBTL1PLAUKDM4EHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | disclosed |