Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzyl Bromide SCHEMBL10545816 | 0.87 | LTA4H (0.69) | LTA4HALDH1A1TRPA1TSHRCA4 | |
| SCHEMBL11175226 | 0.84 | TSHR (0.49) | LTA4HALDH1A1TRPA1TSHRCA4 | |
| SCHEMBL8885157 | 0.83 | LTA4H (0.50) | LTA4HALDH1A1TRPA1TSHRSIGMAR1 | |
| SCHEMBL54543 | 0.82 | CA4 (0.59) | LTA4HALDH1A1TRPA1CA4TDP1 | |
| SCHEMBL30705746 | 0.82 | TRPA1 (0.59) | ALDH1A1TRPA1TSHRTDP1CYP3A4 | |
| SCHEMBL25308490 | 0.82 | CA4 (0.59) | LTA4HALDH1A1TRPA1CA4TDP1 | |
| SCHEMBL49610 | 0.82 | CA4 (0.59) | LTA4HALDH1A1TRPA1CA4TDP1 | |
| SCHEMBL28654739 | 0.82 | IDO1 (0.58) | LTA4HALDH1A1TSHRCYP3A4IDO1 | |
| SCHEMBL2883 | 0.82 | IDO1 (0.58) | LTA4HALDH1A1TSHRCYP3A4IDO1 | |
| SCHEMBL1043929 | 0.82 | LTA4H (0.53) | LTA4HALDH1A1CA4SIGMAR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753676-A | TREATMENT OF PSYCHOLOGICAL DISORDERS, NERVOUS SYSTEM DISORDERS | JOHN WYETH & BROTHER LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5681839-A | BLOCK VOLTAGE GATED POTASSIUM CHANNEL | JOHN WYETH & BROTHER (GB) | 1997-10-28 | — | — | US | disclosed |
| WO-1995021825-A1 | 6-ARYL-(METHYL- OR METHYLIDONE)-QUINOLINE DERIVATIVES AS VOLTAGE-GATED POTASSIUM CHANNEL BLOCKERS | JOHN WYETH & BROTHER LTD. (GB) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021824-A1 | 6-ARYL-(METHYL- OR METHYLIDENE)-QUINOL-2-ONE DERIVATIVES AS VOLTAGE GATED POTASSIUM CHANNEL BLOCKERS | JOHN WYETH & BROTHER LTD (GB) | 1995-08-17 | — | — | WO | disclosed |
| US-4342780-A | 2-AMINO-2-FLUOROMETHYL-3-(SUBSTITUTED) PHENYL PROPIONIC ACIDS AND DERIVATIVES COADMINISTERED WITH DOPAMINE | MERRELL-TORAUDE ET CIE (FR) | 1982-08-03 | — | — | US | disclosed |