Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378571 | 0.77 | ALDH1A1 (0.73) | ALDH1A1CYP3A4MAPTHPGDKDM4E | |
| SCHEMBL7375720 | 0.73 | KDM4E (0.46) | ALDH1A1CYP3A4HPGDKDM4EHSD17B10 | |
| SCHEMBL8405242 | 0.69 | HPGD (0.68) | ALDH1A1CYP3A4MAPTHPGDKDM4E | |
| SCHEMBL12835496 | 0.68 | ALDH1A1 (0.58) | CDK1CCNB1ALDH1A1CYP3A4MAPT | |
| SCHEMBL12835507 | 0.67 | ALDH1A1 (0.70) | ALDH1A1CYP3A4MAPTHPGDKDM4E | |
| SCHEMBL10966059 | 0.67 | MAOB (0.47) | MAPTCYP2D6KMT2AHTTGAA | |
| SCHEMBL7379294 | 0.66 | CYP2D6 (0.48) | CDK1CCNB1ALDH1A1CYP3A4MAPT | |
| SCHEMBL7373845 | 0.65 | MAPT (0.48) | ALDH1A1CYP3A4MAPTHPGDKDM4E | |
| SCHEMBL7087276 | 0.65 | CYP2D6 (0.64) | CDK1CCNB1ALDH1A1CYP3A4MAPT | |
| SCHEMBL7374866 | 0.65 | ALDH1A1 (0.53) | ALDH1A1CYP3A4MAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115718-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017184-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-03-30 | — | — | WO | disclosed |