Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.73 |
| ▸ | HPGD | P15428 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12835507 | 0.86 | ALDH1A1 (0.70) | ALDH1A1CYP3A4HPGDMAPTKDM4E | |
| 8,2'-Dimethoxyflavone SCHEMBL516353 | 0.85 | ALDH1A1 (1.00) | ALDH1A1CYP3A4HPGDMAPTKDM4E | |
| SCHEMBL7374618 | 0.81 | ALDH1A1 (0.82) | ALDH1A1CYP3A4HPGDMAPTKDM4E | |
| SCHEMBL4649947 | 0.78 | CYP3A4 (0.76) | ALDH1A1CYP3A4HPGDMAPTKDM4E | |
| SCHEMBL21822841 | 0.77 | ALDH1A1 (0.74) | ALDH1A1CYP3A4HPGDMAPTKDM4E | |
| SCHEMBL7375725 | 0.77 | CDK1 (0.44) | ALDH1A1CYP3A4HPGDMAPTKDM4E | |
| SCHEMBL6616218 | 0.76 | CYP3A4 (0.73) | ALDH1A1CYP3A4HPGDMAPTKDM4E | |
| SCHEMBL28321911 | 0.76 | ALDH1A1 (0.61) | ALDH1A1CYP3A4HPGDMAPTKDM4E | |
| SCHEMBL28328631 | 0.76 | CYP3A4 (0.61) | ALDH1A1CYP3A4HPGDMAPTKDM4E | |
| SCHEMBL253522 | 0.75 | HPGD (0.78) | ALDH1A1CYP3A4HPGDMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115718-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017184-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-03-30 | — | — | WO | disclosed |