Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1106975 | 0.80 | KMT2A (0.62) | KMT2AALDH1A1TP53LMNAGAA | |
| SCHEMBL9200428 | 0.77 | KMT2A (0.59) | KMT2AALDH1A1TP53LMNAGAA | |
| SCHEMBL24882693 | 0.76 | KMT2A (0.55) | KMT2AALDH1A1TP53LMNAGAA | |
| SCHEMBL18906021 | 0.76 | KMT2A (0.61) | KMT2AALDH1A1TP53LMNAGAA | |
| SCHEMBL15743809 | 0.76 | KMT2A (0.57) | KMT2AALDH1A1TP53LMNAGAA | |
| SCHEMBL7375739 | 0.75 | KMT2A (0.57) | KMT2AALDH1A1TP53LMNAGAA | |
| SCHEMBL21041221 | 0.74 | KMT2A (0.68) | KMT2AALDH1A1TP53LMNAGAA | |
| SCHEMBL8338185 | 0.74 | KMT2A (0.56) | KMT2AALDH1A1TP53LMNAGAA | |
| SCHEMBL1300312 | 0.74 | POLB (0.63) | KMT2AALDH1A1TP53LMNAGAA | |
| SCHEMBL18546466 | 0.73 | ALDH1A1 (0.62) | KMT2AALDH1A1TP53LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863915-B1 | ACYLATED ENOL DERIVATIVES OF ALPHA-KETOESTERS AND ALPHA-KETOAMIDES | HOECHST MARION ROUSSEL INC (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0863915-A1 | ACYLATED ENOL DERIVATIVES OF $g(a)-KETOESTERS AND $g(a)-KETOAMIDES | HOECHST MARION ROUSSEL, INC. (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997020856-A1 | ACYLATED ENOL DERIVATIVES OF α-KETOESTERS AND α-KETOAMIDES | HOECHST MARION ROUSSEL, INC. (US) | 1997-06-12 | — | — | WO | disclosed |