SCHEMBL1106975

SCHEMBL1106975

CC(C)NC(=O)c1ccco1

nearest known ligand 0.64

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.62
ALDH1A1 P00352 4/20 0.62
TP53 P04637 2/20 0.59
LMNA P02545 2/20 0.57
GAA P10253 2/20 0.57
RAB9A P51151 5/20 0.56
MAPT P10636 1/20 0.55
NPC1 O15118 2/20 0.55
HPGD P15428 1/20 0.55
POLB P06746 1/20 0.54
ALOX15 P16050 1/20 0.54
HSD17B10 Q99714 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.53
TSHR P16473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9200428 0.85 KMT2A (0.59) KMT2AALDH1A1TP53LMNAGAA
SCHEMBL27281106 0.84 ALDH1A1 (0.62) KMT2AALDH1A1TP53LMNAGAA
SCHEMBL18546466 0.84 ALDH1A1 (0.62) KMT2AALDH1A1TP53LMNAGAA
SCHEMBL15743809 0.84 KMT2A (0.57) KMT2AALDH1A1TP53LMNAGAA
SCHEMBL18906021 0.84 KMT2A (0.61) KMT2AALDH1A1TP53LMNAGAA
SCHEMBL21041221 0.82 KMT2A (0.68) KMT2AALDH1A1TP53LMNAGAA
SCHEMBL8338185 0.82 KMT2A (0.56) KMT2AALDH1A1TP53LMNAGAA
SCHEMBL22236499 0.82 SMN1; SMN2 (0.57) KMT2AALDH1A1RAB9AHPGDHSD17B10
SCHEMBL3808259 0.81 SMN1; SMN2 (0.57) KMT2AALDH1A1TP53LMNAGAA
SCHEMBL19460314 0.81 CES2 (0.59) KMT2AALDH1A1TP53LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119707952-B Thiadiazolidinone derivative with PTPN2/PTPN1 inhibitory activity, and preparation method and application thereof CHINA PHARMACEUTICAL UNIVERSITY (CN) 2026-05-26 CN disclosed
CN-119707952-A Thiadiazolidinone derivative with PTPN2/PTPN1 inhibitory activity, and preparation method and application thereof 中国药科大学 2025-03-28 CN disclosed
US-20230002364-A1 BENZOTHIOPHENE DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) 2023-01-05 US disclosed
EP-4053110-A1 MODIFIER OF FOUR-MEMBERED RING DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF Shanghai Hansoh Biomedical Co., Ltd. (CN) 2022-09-07 EP disclosed
WO-2021083246-A1 MODIFIER OF FOUR-MEMBERED RING DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF 上海翰森生物医药科技有限公司 2021-05-06 WO disclosed
US-20200102264-A1 MARMELIN ANALOGS AND METHODS OF USE IN CANCER TREATMENT THE UNIVERSITY OF KANSAS (US) 2020-04-02 US disclosed
WO-2019101195-A1 YEATS INHIBITORS AND METHODS OF USE THEREOF THE UNIVERSITY OF HONG KONG (CN) 2019-05-31 WO disclosed
US-20190040080-A1 BIARYL KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2019-02-07 US disclosed
US-9440938-B2 Sulfonamide derivative having PGD2 receptor antagonistic activity SHIONOGI & CO., LTD. (JP) 2016-09-13 US disclosed
US-20150158833-A1 SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY SHIONOGI & CO (JP) 2015-06-11 US disclosed
US-20070232636-A1 Substituted Diaza-Spiro-[5.5]-Undecane Derivaties and Their Use as Neurokinin Antagonists JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-04 US disclosed
US-20070232636-A1 Substituted Diaza-Spiro-[5.5]-Undecane Derivaties and Their Use as Neurokinin Antagonists JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-04 US disclosed
US-7223789-B2 Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them GLENMARK PHARMACEUTICALS S.A. (CH) 2007-05-29 US disclosed
US-7223789-B2 Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them GLENMARK PHARMACEUTICALS S.A. (CH) 2007-05-29 US disclosed
US-20070105855-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS S.A. (CH) 2007-05-10 US disclosed
US-20070105855-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS S.A. (CH) 2007-05-10 US disclosed
US-20070105854-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS S.A. (CH) 2007-05-10 US disclosed
EP-1005463-A1 FURANSULFONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME CENTAUR PHARMACEUTICALS, INC. (US) 2000-06-07 EP disclosed
US-5994396-A Furansulfonic acid derivatives and pharmaceutical compositions containing the same CENTAUR PHARMACEUTICALS, INC. (US) 1999-11-30 US disclosed
WO-1999009022-A1 FURANSULFONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME CENTAUR PHARMACEUTICALS, INC. (US) 1999-02-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150158833-A1 SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY PTGDR, PTGDR2, CNR2 KMT2A 1638/4885ALDH1A1 1440/4885TP53 3795/4885
US-20190040080-A1 BIARYL KINASE INHIBITORS AAK1, CAMKK1, CAMKK2 KMT2A 2483/4885ALDH1A1 2360/4885TP53 3172/4885
US-20070105854-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PDE4A, PDE4B, PDE12 KMT2A 3927/4885ALDH1A1 636/4885TP53 3655/4885
US-20200102264-A1 MARMELIN ANALOGS AND METHODS OF USE IN CANCER TREATMENT COIL, MUC1, MAN2B2 KMT2A 3694/4885ALDH1A1 2830/4885TP53 183/4885
US-20070105855-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PDE4A, PDE4B, PDE12 KMT2A 3927/4885ALDH1A1 636/4885TP53 3655/4885
US-20070232636-A1 Substituted Diaza-Spiro-[5.5]-Undecane Derivaties and Their Use as Neurokinin Antagonists NPSR1, PROKR2, KISS1R KMT2A 1426/4885ALDH1A1 700/4885TP53 4611/4885
US-20230002364-A1 BENZOTHIOPHENE DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF GPER1, GABRQ, GPR39 KMT2A 3242/4885ALDH1A1 3177/4885TP53 4702/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.