Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.36 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.36 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376465 | 0.79 | ALDH1A1 (0.37) | PTPN1S1PR1ALDH1A1IP6K1IP6K3 | |
| SCHEMBL8376467 | 0.79 | ALDH1A1 (0.37) | PTPN1S1PR1ALDH1A1IP6K1IP6K3 | |
| SCHEMBL7374595 | 0.78 | PTPN1 (0.38) | PTPN1ALDH1A1IP6K1IP6K3IP6K2 | |
| SCHEMBL8380011 | 0.78 | PTPN1 (0.38) | NOTUMPTPN1S1PR1ALDH1A1IP6K1 | |
| SCHEMBL8380048 | 0.78 | S1PR1 (0.42) | NOTUMPTPN1S1PR1ALDH1A1IP6K1 | |
| SCHEMBL8129370 | 0.77 | SLC7A5 (0.46) | PTPN1PTGS1 | |
| SCHEMBL7159040 | 0.77 | SLC7A5 (0.46) | PTPN1PTGS1 | |
| SCHEMBL7159035 | 0.77 | SLC7A5 (0.46) | PTPN1PTGS1 | |
| SCHEMBL8375772 | 0.76 | GCGR (0.45) | S1PR1 | |
| SCHEMBL8128585 | 0.75 | KIF11 (0.39) | PTPN1PTGS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994107-A1 | 5-Arylisoxazol-4-yl-substituted 2-amino carboxylic acid compounds | H. LUNDBECK A/S (DK) | 2000-04-19 | — | — | EP | disclosed |
| EP-0726896-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012587-A1 | 5-ARYLISOXAZOL-4-YL-SUBSTITUTED 2-AMINO CARBOXYLIC ACID COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-05-11 | — | — | WO | disclosed |