Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11994167 | 0.80 | BRD4 (0.43) | GCGRHSD11B1S1PR1S1PR3 | |
| SCHEMBL2568160 | 0.77 | PTPN1 (0.55) | HSD11B1S1PR1S1PR3 | |
| SCHEMBL7375744 | 0.76 | NOTUM (0.42) | S1PR1 | |
| SCHEMBL8125246 | 0.75 | NOS1 (0.43) | S1PR1S1PR3 | |
| SCHEMBL8125242 | 0.75 | NOS1 (0.43) | S1PR1S1PR3 | |
| SCHEMBL8380048 | 0.75 | S1PR1 (0.42) | S1PR1S1PR3 | |
| Hydrochloric Acid SCHEMBL8376577 | 0.73 | FAAH (0.43) | HSD11B1S1PR1 | |
| SCHEMBL6581665 | 0.73 | PTPN1 (0.44) | — | |
| SCHEMBL8376467 | 0.73 | ALDH1A1 (0.37) | S1PR1 | |
| Hydrochloric Acid SCHEMBL8379833 | 0.72 | FAAH (0.45) | S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |