Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701360 | 0.73 | MDM2 (0.45) | KDM4EALDH1A1L3MBTL1GAAGLA | |
| SCHEMBL7260450 | 0.69 | KDM4E (0.70) | KDM4EALDH1A1L3MBTL1GAAGLA | |
| SCHEMBL9701832 | 0.68 | KDM4E (0.77) | KDM4EALDH1A1L3MBTL1GAAGLA | |
| SCHEMBL7649493 | 0.67 | KDM4E (0.56) | KDM4EALDH1A1L3MBTL1GAAGLA | |
| SCHEMBL9701530 | 0.66 | KDM4E (0.65) | KDM4EALDH1A1L3MBTL1GAAGLA | |
| SCHEMBL9526447 | 0.65 | GAA (1.00) | KDM4EALDH1A1L3MBTL1GAAGLA | |
| SCHEMBL1201107 | 0.64 | KDM4E (0.53) | KDM4EALDH1A1L3MBTL1GAAGLA | |
| SCHEMBL7256598 | 0.64 | PIM1 (0.58) | KDM4EALDH1A1L3MBTL1GAAGLA | |
| SCHEMBL27154849 | 0.64 | PIM1 (0.62) | KDM4EALDH1A1L3MBTL1GAAGLA | |
| SCHEMBL10985180 | 0.63 | KDM4E (0.55) | KDM4EALDH1A1L3MBTL1GAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | claimed |
| JP-3145466-A | — | — | None | — | — | JP | disclosed |
| US-6479520-B1 | REGULATING APOPTOSIS IN HUMAN CELLS WITH COMPOUNDS SUCH AS: 3-CYANO-6-(2-METHOXY-4-METHYLTHIOIPHENYL)-2(1H)-PYRIDINONE | CELL PATHWAYS, INC. | 2002-11-12 | — | — | US | disclosed |
| US-6046216-A | USEFUL TO INHIBIT THE GROWTH OF NEOPLASTIC CELLS. | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999059584-A1 | COMBINATION OF PHENTOLAMINE AND CYCLIC GMP PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | SCHERING CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |
| JP-H03145466-A | PHENYLPYRIDONE DERIVATIVE | SMITH KLINE LTD | 1991-06-20 | — | — | JP | disclosed |
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | disclosed |