Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | GLA | P06280 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701832 | 0.87 | KDM4E (0.77) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL9526090 | 0.85 | KDM4E (0.74) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL9700707 | 0.83 | KDM4E (0.71) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL7260450 | 0.82 | KDM4E (0.70) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL9701544 | 0.82 | KDM4E (0.70) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL9526262 | 0.81 | ALDH1A1 (0.67) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL9525492 | 0.80 | KDM4E (0.66) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL9701871 | 0.80 | KDM4E (0.66) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL9700724 | 0.80 | KDM4E (0.66) | GAAALDH1A1KDM4EGLAL3MBTL1 | |
| SCHEMBL9701530 | 0.79 | KDM4E (0.65) | GAAALDH1A1KDM4EGLAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890697-B1 | AZINONE AND DIAZINONE V3 INHIBITORS FOR DEPRESSION AND STRESS DISORDERS | PHARMACOPEIA LLC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8350043-B2 | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-8350043-B2 | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20070037822-A1 | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| US-20070037822-A1 | Azinone and diazinone V3 inhibitors for depression and stress disorders | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| EP-0550576-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037822-A1 | Azinone and diazinone V3 inhibitors for depression and stress disorders | HTR3C, HTR3A, AZI2 | GAA 2862/4885ALDH1A1 200/4885KDM4E 561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.