Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | STAT1 | P42224 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | NAAA | Q02083 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | PREP | P48147 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10371234 | 0.95 | NPC1 (0.78) | NPC1TDP1RAB9AMEN1PKM | |
| SCHEMBL8599293 | 0.93 | NPC1 (0.81) | NPC1TDP1RAB9AMEN1PKM | |
| SCHEMBL17087869 | 0.88 | NPC1 (0.96) | NPC1TDP1RAB9AMEN1PKM | |
| SCHEMBL6285963 | 0.88 | NPC1 (0.96) | NPC1TDP1RAB9AMEN1PKM | |
| SCHEMBL3700679 | 0.86 | NPC1 (1.00) | NPC1TDP1RAB9AMEN1PKM | |
| SCHEMBL8097277 | 0.84 | HPGD (0.63) | NPC1RAB9AMEN1KMT2ANAAA | |
| SCHEMBL8084492 | 0.84 | TRPV1 (0.60) | NPC1TDP1NAAATRPV1 | |
| SCHEMBL9557071 | 0.84 | NPC1 (0.58) | NPC1TDP1RAB9ANAAA | |
| SCHEMBL7447522 | 0.84 | NAAA (0.58) | NPC1TDP1RAB9APKMKMT2A | |
| SCHEMBL1953978 | 0.84 | FKBP1A (0.80) | NPC1TDP1RAB9ANAAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714292-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE INC (US) | 1996-10-09 | — | — | EP | claimed |
| EP-0714292-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-06-05 | — | — | EP | claimed |
| WO-1995000131-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INCORPORATED (US) | 1995-01-05 | — | — | WO | claimed |