Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.40 |
| ▸ | CTSS | P25774 | 4/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.33 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.33 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.33 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.33 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.33 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.33 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.33 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | LONP1 | P36776 | 1/20 | 0.33 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.33 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.33 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.33 |
| ▸ | PSMA6 | P60900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404685 | 0.92 | REN (0.36) | RENCTSSPSMB11PSMA7PSMB1 | |
| SCHEMBL7409474 | 0.91 | REN (0.37) | RENCTSSPSMB11PSMA7PSMB1 | |
| SCHEMBL7369296 | 0.90 | REN (0.39) | RENCTSSPSMB11PSMA7PSMB1 | |
| SCHEMBL7366123 | 0.88 | CTSS (0.33) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL7321725 | 0.82 | REN (0.45) | REN | |
| SCHEMBL7367978 | 0.78 | CTSS (0.37) | RENCTSSPSMB11PSMA7PSMB1 | |
| SCHEMBL7320151 | 0.77 | REN (0.41) | RENPSMB1PSMB8PSMB9PSMB5 | |
| SCHEMBL7382471 | 0.76 | CTSS (0.39) | RENCTSSPSMB11PSMA7PSMB1 | |
| SCHEMBL7320165 | 0.76 | REN (0.40) | RENCTSSPSMB1PSMB8PSMB9 | |
| SCHEMBL7320145 | 0.76 | REN (0.40) | RENCTSSPSMB1PSMB8PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |