Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LAP3 | P28838 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.37 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.37 |
| ▸ | GRN | P28799 | 2/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376495 | 1.00 | ALDH1A1 (0.43) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL7375640 | 0.86 | PPID (0.39) | GAAMAPTADAM17MMP1MMP3 | |
| SCHEMBL7373729 | 0.84 | ALDH1A1 (0.41) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL7376049 | 0.84 | ALDH1A1 (0.41) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL7373736 | 0.84 | ALDH1A1 (0.41) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL9502827 | 0.83 | ALDH1A1 (0.46) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL9502831 | 0.83 | ALDH1A1 (0.46) | ALDH1A1LAP3MEN1LMNAKMT2A | |
| SCHEMBL7319533 | 0.80 | CTSK (0.47) | — | |
| SCHEMBL7318546 | 0.80 | CTSK (0.47) | — | |
| SCHEMBL7318537 | 0.80 | CTSK (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320118-B1 | PEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY | BEECHAM GROUP PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| US-5212163-A | Phosphonate dipeptide or tripeptide derivatives as collagenase inhibitors for treatment of connective tissue disorders | BEECHAM GROUP P.L.C. (GB) | 1993-05-18 | — | — | US | disclosed |
| EP-0401963-A1 | Phosphonopeptides with collagenase inhibiting activity | Beecham Group p.l.c. (GB) | 1990-12-12 | — | — | EP | disclosed |
| US-4935404-A | ANTIARTHRITIC AGENTS; RHEUMATIC DISEASES | BEECHAM GROUP P.L.C. OF BEECHAM HOUSE (GB) | 1990-06-19 | — | — | US | disclosed |
| EP-0320118-A2 | Peptides with collagenase inhibiting activity | BEECHAM GROUP PLC (GB) | 1989-06-14 | — | — | EP | disclosed |