Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088667 | 0.89 | KMT2A (0.42) | SMN1; SMN2KMT2AMAPTCFTRMEN1 | |
| SCHEMBL8090742 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL8084409 | 0.85 | ALDH1A1 (0.35) | KMT2AMEN1ALDH1A1GAACYP3A4 | |
| SCHEMBL8084934 | 0.85 | CFTR (0.38) | SMN1; SMN2KMT2AMAPTCFTRALDH1A1 | |
| SCHEMBL8085303 | 0.84 | CHRM2 (0.34) | KMT2AMEN1ALDH1A1CYP3A4TDP1 | |
| SCHEMBL8085352 | 0.83 | PDE4A (0.39) | CYP1A2KDM4E | |
| SCHEMBL8090547 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2AMAPTCFTRMEN1 | |
| SCHEMBL8090154 | 0.82 | TDP1 (0.34) | KMT2AMAPTMEN1ALDH1A1CYP3A4 | |
| SCHEMBL8084419 | 0.81 | CFTR (0.38) | SMN1; SMN2KMT2AMAPTCFTRMEN1 | |
| SCHEMBL7376992 | 0.81 | AAK1 (0.35) | KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |