Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.59 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | CTSC | P53634 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389264 | 0.88 | NPSR1 (0.58) | MCHR1SLC6A12TMEM97SIGMAR1NPC1 | |
| SCHEMBL20147581 | 0.84 | HRH3 (0.68) | MCHR1SLC6A12TMEM97SIGMAR1NPC1 | |
| SCHEMBL21652025 | 0.81 | MCHR1 (0.68) | MCHR1SLC6A12TMEM97SIGMAR1NPC1 | |
| SCHEMBL4749226 | 0.79 | NPC1 (0.67) | MCHR1SLC6A12TMEM97SIGMAR1NPC1 | |
| SCHEMBL14021836 | 0.79 | NPC1 (0.67) | MCHR1SLC6A12TMEM97SIGMAR1NPC1 | |
| Fk-962 SCHEMBL239762 | 0.77 | KMT2A (0.69) | MCHR1SLC6A12TMEM97SIGMAR1NPC1 | |
| SCHEMBL532160 | 0.77 | RAB9A (0.83) | MCHR1SLC6A12TMEM97SIGMAR1NPC1 | |
| SCHEMBL14679122 | 0.76 | NPC1 (0.58) | NPC1RAB9AKMT2ATSHRMEN1 | |
| SCHEMBL6379927 | 0.76 | MCHR1 (0.69) | MCHR1SLC6A12TMEM97SIGMAR1NPC1 | |
| SCHEMBL14004335 | 0.76 | NPC1 (0.61) | MCHR1SLC6A12TMEM97SIGMAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-A2 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999006387-A2 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-02-11 | — | — | WO | disclosed |