Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.68 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.68 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | CCR3 | P51677 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | CTSC | P53634 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1560294 | 0.87 | SLC6A5 (0.58) | MCHR1SLC6A12TMEM97SIGMAR1RECQL | |
| SCHEMBL18286474 | 0.85 | CARM1 (0.72) | MCHR1SLC6A12TMEM97SIGMAR1KMT2A | |
| SCHEMBL21651961 | 0.84 | CCR3 (0.67) | MCHR1CCR3KMT2AL3MBTL1HTR7 | |
| SCHEMBL4749226 | 0.84 | NPC1 (0.67) | MCHR1SLC6A12TMEM97SIGMAR1CCR3 | |
| SCHEMBL11223577 | 0.83 | MCHR1 (0.65) | MCHR1SLC6A12TMEM97SIGMAR1CCR3 | |
| SCHEMBL6379927 | 0.83 | MCHR1 (0.69) | MCHR1SLC6A12TMEM97SIGMAR1CCR3 | |
| SCHEMBL3537578 | 0.82 | L3MBTL1 (0.52) | MCHR1SLC6A12TMEM97SIGMAR1RECQL | |
| SCHEMBL6378472 | 0.81 | MCHR1 (0.66) | MCHR1SLC6A12TMEM97SIGMAR1CCR3 | |
| SCHEMBL7377018 | 0.81 | MCHR1 (0.59) | MCHR1SLC6A12TMEM97SIGMAR1CCR3 | |
| SCHEMBL1425074 | 0.81 | SIGMAR1 (1.00) | MCHR1SLC6A12TMEM97SIGMAR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200383966-A9 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-12-10 | — | — | US | disclosed |
| US-20200030311-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200383966-A9 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | MCHR1 1063/4885SLC6A12 4430/4885TMEM97 4256/4885 |
| US-20200030311-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | MCHR1 1063/4885SLC6A12 4430/4885TMEM97 4256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.