Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GUSB | P08236 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383662 | 0.90 | KDM4E (0.50) | FGFR1FGFR2MEN1KMT2AFGFR3 | |
| SCHEMBL7382807 | 0.78 | FGFR1 (0.46) | FGFR1FGFR2MEN1KMT2AFGFR3 | |
| SCHEMBL13153580 | 0.76 | GUSB (0.70) | CHEK2HPGDGUSBKDM4EMAPT | |
| SCHEMBL13302236 | 0.75 | HTR1A (0.55) | MEN1KMT2A | |
| SCHEMBL14883366 | 0.74 | TNKS (0.51) | FGFR1FGFR2MEN1KMT2AFGFR3 | |
| SCHEMBL31695045 | 0.74 | CHEK2 (0.55) | MEN1KMT2ACHEK2HPGDKDM4E | |
| SCHEMBL6802033 | 0.73 | FGFR1 (0.51) | FGFR1FGFR2MEN1KMT2AFGFR3 | |
| SCHEMBL4502490 | 0.73 | KDM4E (0.48) | CHEK1CHEK2HPGDKDM4EMAPT | |
| SCHEMBL2723566 | 0.72 | KDM4E (0.49) | CHEK1CHEK2HPGDKDM4E | |
| SCHEMBL14877000 | 0.71 | GUSB (0.60) | FGFR1FGFR2HPGDGUSBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980374-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049169-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 1998-11-05 | — | — | WO | disclosed |