Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.39 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7451025 | 0.85 | ITGB3 (0.46) | POLBEP300KDM4EFNTAFNTB | |
| SCHEMBL7649303 | 0.83 | KMT2A (0.44) | POLBEP300KDM4ETP53FNTA | |
| SCHEMBL12208592 | 0.82 | PRMT5 (0.50) | POLBITGB3ITGA2BKCNH2 | |
| SCHEMBL7684658 | 0.79 | EP300 (0.43) | POLBEP300ITGB3ITGA2BCTSS | |
| SCHEMBL9176077 | 0.79 | POLB (0.68) | POLBKDM4ETP53ITGB3ITGA2B | |
| SCHEMBL7660300 | 0.78 | CCR5 (0.42) | POLBEP300KDM4EFNTAFNTB | |
| SCHEMBL7448038 | 0.77 | ALDH1A1 (0.43) | POLBEP300KDM4EFNTAFNTB | |
| SCHEMBL7651092 | 0.76 | EP300 (0.44) | POLBEP300FNTAFNTBITGB3 | |
| SCHEMBL25160520 | 0.75 | FNTA (0.52) | KDM4ETP53FNTAFNTBCHRNA10 | |
| SCHEMBL20644621 | 0.75 | FNTA (0.52) | KDM4ETP53FNTAFNTBCHRNA10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188402-C | Piperazinone derivatives and uses thereof | LAFON LABOR (FR) | 2005-02-09 | — | — | CN | disclosed |
| US-6344456-B1 | ANTICOAGULANTS | LABORATOIRE L. LAFON (FR) | 2002-02-05 | — | — | US | disclosed |
| US-6335337-B1 | ANTICOAGULANTS | LABORATOIRE L. LAFON (FR) | 2002-01-01 | — | — | US | disclosed |
| CN-1309648-A | Piperazinone derivs. and their uses | LAFON LABOR (FR) | 2001-08-22 | — | — | CN | disclosed |
| EP-1098889-A1 | SUBSTITUTED PIPERAZONES AND THEIR THERAPEUTIC USES | LABORATOIRE L. LAFON (FR) | 2001-05-16 | — | — | EP | disclosed |
| EP-1098888-A1 | PIPERAZINONE DERIVATIVES AND THEIR USES | LABORATOIRE L. LAFON (FR) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004001-A1 | SUBSTITUTED PIPERAZONES AND THEIR THERAPEUTIC USES | LABORATOIRE L. LAFON (FR) | 2000-01-27 | — | — | WO | disclosed |
| WO-2000004000-A1 | PIPERAZINONE DERIVATIVES AND THEIR USES | LABORATOIRE L. LAFON (FR) | 2000-01-27 | — | — | WO | disclosed |