Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | VDR | P11473 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14365065 | 0.84 | CCNB2 (0.50) | CCNB2CDK1CCNB1CCNB3KIF11 | |
| SCHEMBL29443497 | 0.82 | KIF11 (0.46) | CCNB2CDK1CCNB1CCNB3KIF11 | |
| SCHEMBL9457713 | 0.80 | KDM4E (0.53) | CCNB2CDK1CCNB1CCNB3KIF11 | |
| SCHEMBL8247023 | 0.79 | CCNB2 (0.46) | CCNB2CDK1CCNB1CCNB3KIF11 | |
| SCHEMBL23429368 | 0.76 | CCNB2 (0.53) | CCNB2CDK1CCNB1CCNB3KIF11 | |
| SCHEMBL13301938 | 0.76 | AHR (0.55) | KIF11ALDH1A1HSD17B10GPR3HTT | |
| SCHEMBL10280325 | 0.75 | CCNB2 (0.56) | CCNB2CDK1CCNB1CCNB3KIF11 | |
| SCHEMBL30234429 | 0.75 | CCNB2 (0.56) | CCNB2CDK1CCNB1CCNB3KIF11 | |
| SCHEMBL7373159 | 0.74 | DRD2 (0.52) | KIF11ALDH1A1HSD17B10GPR3HTT | |
| SCHEMBL8997990 | 0.73 | VDR (0.67) | CCNB2CDK1CCNB1CCNB3KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420086-B1 | Pyrimidoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-12-13 | — | — | EP | disclosed |
| US-5256780-A | Serotonin antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| US-5180728-A | Antagonists of 5-hydroxytryptamine | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1993-01-19 | — | — | US | disclosed |
| EP-0420086-A2 | Pyrimidoindole derivatives and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |