Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375353 | 0.80 | MEN1 (0.46) | MEN1KMT2AGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL7449500 | 0.71 | MAPT (0.41) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7409106 | 0.70 | MEN1 (0.41) | POLBMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL7391592 | 0.64 | MAPK1 (0.47) | KMT2AGAAALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL7410701 | 0.62 | TP53 (0.37) | POLBMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL6421307 | 0.61 | ALDH1A1 (0.54) | POLBMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL11864635 | 0.60 | PPARG (0.76) | GAAALDH1A1LMNA | |
| SCHEMBL2027600 | 0.60 | LMNA (0.59) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6878047 | 0.60 | PKM (0.57) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL31424955 | 0.60 | PKM (0.57) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1079835-A4 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-10-29 | — | — | EP | disclosed |
| EP-1079835-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059591-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1999-11-25 | — | — | WO | disclosed |