Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.67 |
| ▸ | CA2 | P00918 | 3/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378257 | 1.00 | CA1 (0.67) | CA1CA2CA12CA9CYP1A2 | |
| SCHEMBL6662254 | 0.80 | CA12 (1.00) | CA1CA2CA12CA9CYP1A2 | |
| SCHEMBL8369822 | 0.80 | ALDH1A1 (0.73) | CA1CA2CA12CA9CYP1A2 | |
| SCHEMBL8369820 | 0.80 | ALDH1A1 (0.73) | CA1CA2CA12CA9CYP1A2 | |
| SCHEMBL8040828 | 0.79 | CA1 (0.67) | CA1CA2CA12CA9CYP1A2 | |
| SCHEMBL8040824 | 0.79 | CA1 (0.67) | CA1CA2CA12CA9CYP1A2 | |
| SCHEMBL8029217 | 0.79 | ALDH1A1 (0.68) | CA1CA2CA12CA9CYP1A2 | |
| SCHEMBL26163200 | 0.79 | ALOX15 (0.52) | CA1CA2CYP1A2ALOX15TSHR | |
| SCHEMBL8029219 | 0.79 | ALDH1A1 (0.68) | CA1CA2CA12CA9CYP1A2 | |
| SCHEMBL8046164 | 0.79 | TSHR (0.57) | CA1CA2CA12CA9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658546-B1 | Novel 3-pyrazolecarboxamide derivatives with cannabinoid receptor affinity | SANOFI SYNTHELABO (FR) | 2001-05-23 | — | — | EP | disclosed |
| EP-0868420-B1 | 3-PYRAZOLECARBOXAMIDE DERIVATIVES HAVING CANNABINOID RECEPTOR AFFINITY | SANOFI SYNTHELABO (FR) | 2000-03-29 | — | — | EP | disclosed |
| EP-0885889-A2 | Process for the preparation of pyrazole-3-carboxylic acids | SANOFI (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0868420-A1 | 3-PYRAZOLECARBOXAMIDE DERIVATIVES HAVING CANNABINOID RECEPTOR AFFINITY | SANOFI (FR) | 1998-10-07 | — | — | EP | disclosed |
| WO-1997021682-A1 | 3-PYRAZOLECARBOXAMIDE DERIVATIVES HAVING CANNABINOID RECEPTOR AFFINITY | SANOFI (FR) | 1997-06-19 | — | — | WO | disclosed |
| EP-0658546-A1 | Novel 3-pyrazolecarboxamide derivatives with cannabinoid receptor affinity | SANOFI (FR) | 1995-06-21 | — | — | EP | disclosed |