Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667935 | 1.00 | MME (0.44) | MMEACECPA1ACE2SLC22A6 | |
| SCHEMBL4748392 | 1.00 | MME (0.44) | MMEACECPA1ACE2SLC22A6 | |
| SCHEMBL13573121 | 0.84 | SLC22A6 (0.48) | SLC22A6SMN1; SMN2GPR84MAPTGABRR1 | |
| SCHEMBL29586601 | 0.82 | SLC22A6 (0.37) | MMEACECPA1ACE2SLC22A6 | |
| SCHEMBL26106950 | 0.82 | SLC22A6 (0.48) | MMEACECPA1ACE2SLC22A6 | |
| SCHEMBL14220059 | 0.82 | SLC22A6 (0.37) | MMEACECPA1ACE2SLC22A6 | |
| SCHEMBL1047606 | 0.82 | SLC22A6 (0.48) | MMEACECPA1ACE2SLC22A6 | |
| SCHEMBL9275230 | 0.82 | SLC22A6 (0.37) | MMEACECPA1ACE2SLC22A6 | |
| SCHEMBL4633347 | 0.81 | GPR84 (0.45) | SLC22A6SMN1; SMN2GPR84MAPTGABRR1 | |
| SCHEMBL10599123 | 0.81 | GPR84 (0.45) | SLC22A6SMN1; SMN2GPR84MAPTGABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019386-A1 | REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998038179-A1 | REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1998-09-03 | — | — | WO | disclosed |