Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.35 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407222 | 0.90 | KDM4E (0.40) | KDM4EPOLBNPC1HTTRAB9A | |
| SCHEMBL7372340 | 0.89 | SIRT5 (0.41) | SIRT5POLBNAMPTALDH1A1 | |
| SCHEMBL7377978 | 0.86 | KCNK3 (0.40) | KDM4EPOLBNPC1HTTRAB9A | |
| SCHEMBL7379148 | 0.83 | PSMD14 (0.40) | KDM4EPOLBNPC1HTTRAB9A | |
| SCHEMBL7237846 | 0.78 | MAPK13 (0.36) | SIRT5KDM4EPOLBNPC1HTT | |
| SCHEMBL7412126 | 0.77 | DPP4 (0.39) | POLBNAMPTSLC2A1GAATAAR1 | |
| SCHEMBL7554629 | 0.75 | KCNK3 (0.47) | KCNK3KCNK9 | |
| SCHEMBL7410232 | 0.74 | NR1H4 (0.39) | KDM4EPOLBNPC1HTTRAB9A | |
| SCHEMBL22627384 | 0.71 | CYP11B1 (0.64) | KDM4EPOLBNPC1HTTRAB9A | |
| SCHEMBL22615010 | 0.71 | CYP11B1 (0.44) | KDM4EPOLBNPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002002557-A2 | 2-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES: A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2002-01-10 | — | — | WO | disclosed |