Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.53 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10843997 | 0.90 | LMNA (0.56) | SMN1; SMN2TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL10511441 | 0.82 | HDAC1 (0.41) | TSHRALDH1A1LMNAMAOBMAOA | |
| SCHEMBL10846772 | 0.82 | CARM1 (0.47) | SMN1; SMN2TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL5902509 | 0.80 | MAOB (0.49) | TSHRMAOBL3MBTL1 | |
| SCHEMBL615516 | 0.78 | TSHR (0.65) | SMN1; SMN2TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL7055109 | 0.77 | CARM1 (0.75) | SMN1; SMN2TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL7937668 | 0.77 | CARM1 (0.58) | SMN1; SMN2TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL7235029 | 0.77 | TSHR (0.58) | SMN1; SMN2TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL8487152 | 0.76 | HTR1D (0.62) | SMN1; SMN2TSHRALDH1A1HTR1DHTR1B | |
| SCHEMBL7378478 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRCARM1PRMT6PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173933-B1 | 1,6-NAPHTHYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENT CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1989-11-29 | — | — | EP | claimed |
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | claimed |
| EP-0111455-A2 | Unsaturated lactones | CIBA-GEIGY AG (CH) | 1984-06-20 | — | — | EP | claimed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | claimed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | claimed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | claimed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | claimed |
| EP-0294601-B1 | TRANSDERMAL DELIVERY OF PHARMACEUTICALS | AMERICAN CYANAMID COMPANY (US) | 1993-01-20 | — | — | EP | disclosed |
| US-5160734-A | Complex with polyoxyethylene-polyoxypropylene copolymer | AMERICAN CYANAMID COMPANY (US) | 1992-11-03 | — | — | US | disclosed |
| EP-0317780-B1 | SUSTAINED (CONTROLLED) RELEASE DELIVERY SYSTEM FOR SUBSTITUTED DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS | AMERICAN CYANAMID COMPANY (US) | 1992-05-20 | — | — | EP | disclosed |
| US-5114946-A | An enantiomorphs and a vehicle for drug deliversy | AMERICAN CYANAMID COMPANY (US) | 1992-05-19 | — | — | US | disclosed |
| US-5001139-A | Enchancers for the transdermal flux of nivadipine | AMERICAN CYANAMID COMPANY (US) | 1991-03-19 | — | — | US | disclosed |
| US-4992445-A | Enantiomorphs of active chiral compounds in vehicle | AMERICAN CYANAMID CO. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0127150-A2 | 2,6-Disubstituted-1,4-dihydropyridine derivative, process for the preparation of the same and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-12-05 | — | — | EP | disclosed |
| EP-0111455-A2 | Unsaturated lactones | CIBA-GEIGY AG (CH) | 1984-06-20 | — | — | EP | disclosed |
| EP-0111453-A1 | Amide derivatives | CIBA-GEIGY AG (CH) | 1984-06-20 | — | — | EP | disclosed |
| EP-0083315-A2 | Pyridyl-N-oxides, processes for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1983-07-06 | — | — | EP | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |