Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 2/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375822 | 1.00 | HRH3 (0.58) | HRH3TSHRLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7375876 | 0.99 | TSHR (0.60) | HRH3TSHRLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7376357 | 0.99 | TSHR (0.60) | HRH3TSHRLMNAMEN1KMT2A | |
| SCHEMBL7375128 | 0.89 | ALDH1A1 (0.59) | HRH3LMNAMEN1KMT2AADRA1A | |
| Hydrochloric Acid SCHEMBL7372372 | 0.88 | ALDH1A1 (0.60) | HRH3LMNAMEN1KMT2AHTT | |
| Primaperone SCHEMBL310299 | 0.87 | TSHR (0.74) | HRH3TSHRMEN1KMT2AADRA1A | |
| Primaperone SCHEMBL364809 | 0.85 | TSHR (0.76) | HRH3TSHRMEN1KMT2AADRA1A | |
| SCHEMBL4496558 | 0.85 | TSHR (0.76) | HRH3TSHRMEN1KMT2AADRA1A | |
| SCHEMBL14435454 | 0.83 | ALDH1A1 (0.78) | HRH3TSHRLMNAMEN1KMT2A | |
| SCHEMBL492212 | 0.83 | HRH3 (0.77) | HRH3TSHRLMNAADRA1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724577-A1 | HETEROCYCLIC AMINES FOR TREATING ISCHAEMIC STROKES | SMITHKLINE BEECHAM PLC (GB) | 1996-08-07 | — | — | EP | claimed |
| WO-1995011238-A1 | HETEROCYCLIC AMINES FOR TREATING ISCHAEMIC STROKES | SMITHKLINE BEECHAM PLC (GB) | 1995-04-27 | — | — | WO | claimed |
| EP-0724577-A1 | HETEROCYCLIC AMINES FOR TREATING ISCHAEMIC STROKES | SMITHKLINE BEECHAM PLC (GB) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011238-A1 | HETEROCYCLIC AMINES FOR TREATING ISCHAEMIC STROKES | SMITHKLINE BEECHAM PLC (GB) | 1995-04-27 | — | — | WO | disclosed |