Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 7/20 | 0.59 |
| ▸ | NOS1 | P29475 | 5/20 | 0.59 |
| ▸ | NOS3 | P29474 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041424 | 0.90 | NOS1 (0.56) | NOS2NOS1NOS3AURKAADORA1 | |
| SCHEMBL9648738 | 0.89 | PI4KA (0.57) | NOS2NOS1NOS3AURKAADORA1 | |
| SCHEMBL9406720 | 0.88 | PI4KA (0.56) | NOS2NOS1NOS3AURKAPI4KA | |
| SCHEMBL3211252 | 0.86 | ADORA1 (0.57) | NOS2NOS1NOS3AURKAADORA1 | |
| SCHEMBL9406926 | 0.82 | ADORA1 (0.43) | NOS2NOS1NOS3ADORA1ADORA3 | |
| SCHEMBL3964555 | 0.82 | ADORA1 (0.43) | NOS2NOS1NOS3ADORA1ADORA3 | |
| SCHEMBL31569166 | 0.81 | NOS2 (0.53) | NOS2NOS1NOS3AURKAADORA1 | |
| SCHEMBL9406899 | 0.80 | ADORA1 (0.42) | NOS2NOS1NOS3ADORA1ADORA3 | |
| SCHEMBL9406654 | 0.79 | NOS2 (0.58) | NOS2NOS1NOS3AURKAADORA1 | |
| SCHEMBL21533573 | 0.77 | NOS2 (0.56) | NOS2NOS1NOS3AURKAPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519138-A | ANGIOTENSIN ANTAGONIST | DR. KARL THOMAE GMBH (DE) | 1996-05-21 | — | — | US | disclosed |
| EP-0517812-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1995-10-18 | — | — | EP | disclosed |
| US-5449682-A | Angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5387684-A | For treatment and prophylaxis of angiotensin II-mediated diseases such as circulatory diseases of hypertension and heart failure | THE GREEN CROSS CORPORATION (JP) | 1995-02-07 | — | — | US | disclosed |
| US-5332744-A | Hypotensive, congestive heart failure, intraocular pressure | MERCK & CO., INC. (US) | 1994-07-26 | — | — | US | disclosed |
| EP-0602246-A1 | ISOINDAZOLE COMPOUND | THE GREEN CROSS CORPORATION (JP) | 1994-06-22 | — | — | EP | disclosed |
| US-5240938-A | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring | MERCK & CO., INC. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0543491-A2 | Angiotensin II antagonists having a substituted 1,3-benzodioxolering or 1,3-benzodithiolering | MERCK & CO. INC. (US) | 1993-05-26 | — | — | EP | disclosed |
| EP-0529253-A1 | Phenylalkylderivatives, compounds containing them and process for their fabrication | Dr. Karl Thomae GmbH (DE) | 1993-03-03 | — | — | EP | disclosed |
| US-5187159-A | Hypotensive agents, psychological disorders | MERCK & CO., INC. (US) | 1993-02-16 | — | — | US | disclosed |
| US-5157026-A | Oxo-purines as angiotensin II antagonists | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0508723-A1 | Angiotensin II antagonists incorporating an indole or dihydroindole | MERCK & CO. INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5151435-A | Hypotensive agents, glaucoma and cognition activators | MERCK & CO., INC. (US) | 1992-09-29 | — | — | US | disclosed |
| US-5128327-A | Hypotensive agents; congestive heart failure; antidepressants; anxiolytic agents; cognition activators | MERCK & CO., INC. (US) | 1992-07-07 | — | — | US | disclosed |
| US-5102880-A | Biphenyl imidazotriazine derivatives; Hypotensive and cardiotonic agents | MERCK & CO., INC. (US) | 1992-04-07 | — | — | US | disclosed |
| US-5087702-A | Fermentation of streptomyces in the presence of angiotensin II receptor antagonist | MERCK & CO., INC. (US) | 1992-02-11 | — | — | US | disclosed |
| US-5066586-A | Fermenting 3-((2'-tetrazol-5-yl-biphenyl-4-yl)methyl)-7-methyl-2-propyl-3H-imidazo(4,5 -B)pyridine to oxidize | MERCK & CO., INC. (US) | 1991-11-19 | — | — | US | disclosed |
| US-5053329-A | Aerobic culturing of actinoplanes yields hypotensive agent | MERCK & CO., INC. (US) | 1991-10-01 | — | — | US | disclosed |
| WO-1991011999-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |
| EP-0400974-A2 | Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | disclosed |