Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.52 |
| ▸ | KHK | P50053 | 9/20 | 0.48 |
| ▸ | DGAT2 | Q96PD7 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984355 | 0.87 | DGAT2 (0.48) | KHKDGAT2 | |
| SCHEMBL20167493 | 0.81 | DGAT2 (0.44) | DGAT2MEN1KMT2A | |
| SCHEMBL6795458 | 0.79 | KHK (0.49) | KHK | |
| SCHEMBL7981992 | 0.79 | PDE4A (0.51) | KHKDGAT2 | |
| SCHEMBL4261343 | 0.77 | SLC22A12 (0.60) | SLC22A12MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13350302 | 0.74 | DGAT2 (0.41) | KHKDGAT2 | |
| SCHEMBL7382833 | 0.74 | SLC22A12 (0.56) | SLC22A12MEN1NPC1RAB9AKMT2A | |
| SCHEMBL20166434 | 0.73 | DGAT2 (0.73) | DGAT2 | |
| SCHEMBL6794875 | 0.72 | PDE4B (0.44) | KHKDGAT2 | |
| SCHEMBL6794879 | 0.72 | PDE4B (0.44) | KHKDGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | claimed |
| EP-0931075-A1 | INDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE (PDE) TYPE IV AND THE PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) | PFIZER INC. (US) | 1999-07-28 | — | — | EP | claimed |
| WO-1998009961-A1 | INDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE (PDE) TYPE IV AND THE PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) | PFIZER INC. (US) | 1998-03-12 | — | — | WO | claimed |
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |
| EP-0931075-A1 | INDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE (PDE) TYPE IV AND THE PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) | PFIZER INC. (US) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998009961-A1 | INDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE (PDE) TYPE IV AND THE PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) | PFIZER INC. (US) | 1998-03-12 | — | — | WO | disclosed |