Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 14/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | KHK | P50053 | 4/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379243 | 0.87 | SLC22A12 (0.52) | DGAT2KHK | |
| SCHEMBL20166406 | 0.83 | DGAT2 (0.47) | DGAT2CCR1PARP1 | |
| SCHEMBL27272748 | 0.79 | SLC22A12 (0.44) | PARP1 | |
| SCHEMBL6795458 | 0.76 | KHK (0.49) | KHK | |
| SCHEMBL20167169 | 0.76 | DGAT2 (0.75) | DGAT2 | |
| SCHEMBL7981706 | 0.76 | KDM4E (0.44) | — | |
| SCHEMBL3598897 | 0.76 | SLC22A12 (0.42) | KHKPARP1 | |
| SCHEMBL20594197 | 0.76 | FFAR4 (0.41) | KHK | |
| SCHEMBL12264383 | 0.74 | PDE4D (0.47) | — | |
| SCHEMBL13350302 | 0.73 | DGAT2 (0.41) | DGAT2KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |