Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.51 |
| ▸ | DGAT2 | Q96PD7 | 12/20 | 0.49 |
| ▸ | KHK | P50053 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326260 | 0.80 | PDE4D (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7379243 | 0.79 | SLC22A12 (0.52) | DGAT2KHK | |
| SCHEMBL7984355 | 0.78 | DGAT2 (0.48) | DGAT2KHK | |
| SCHEMBL8326256 | 0.77 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8358690 | 0.77 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5964482 | 0.77 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8325842 | 0.76 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13350302 | 0.72 | DGAT2 (0.41) | DGAT2KHK | |
| SCHEMBL6795458 | 0.69 | KHK (0.49) | PDE4APDE4BPDE4CPDE4DKHK | |
| SCHEMBL3470863 | 0.69 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |