Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958910 | 0.83 | NOTUM (0.50) | CYP1A2CYP3A4SMN1; SMN2HPGDLMNA | |
| SCHEMBL4698108 | 0.82 | MAPT (0.54) | CYP1A2HPGDLMNAHSD17B10MAPT | |
| SCHEMBL4105190 | 0.76 | ALDH1A1 (0.61) | CYP1A2CYP3A4SMN1; SMN2HPGDLMNA | |
| SCHEMBL4519599 | 0.75 | ALDH1A1 (0.61) | SMN1; SMN2LMNAMAPTKDM4EGAA | |
| SCHEMBL29025896 | 0.71 | CYP1A2 (0.61) | CYP1A2CYP3A4SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL7373895 | 0.71 | MAPT (0.36) | CYP1A2CYP3A4SMN1; SMN2HPGDLMNA | |
| SCHEMBL7373896 | 0.71 | MAPT (0.36) | CYP1A2CYP3A4SMN1; SMN2HPGDLMNA | |
| SCHEMBL3188766 | 0.71 | CYP1A2 (0.45) | CYP1A2CYP3A4SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL4928504 | 0.70 | KDM4E (0.47) | CYP1A2SMN1; SMN2HPGDLMNAHSD17B10 | |
| SCHEMBL4518905 | 0.69 | CYP3A4 (0.44) | CYP1A2CYP3A4SMN1; SMN2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0134535-B1 | 1,6-NAPHTHYRIDIN DERIVATIVES USEFUL AS CARDIOTONICS AND PREPARATION THEREOF | STERLING DRUG INC. (US) | 1988-10-26 | — | — | EP | disclosed |
| EP-0101952-B1 | 5-ALKYL-1,6-NAPHTHYRIDIN-2(1H)-ONES, INTERMEDIATES, THEIR PREPARATION AND THEIR CARDIOTONIC USE | STERLING DRUG INC. (US) | 1987-09-23 | — | — | EP | disclosed |
| EP-0204335-A2 | 2(1H)-Pyridin-ones useful as intermediates | STERLING DRUG INC. (US) | 1986-12-10 | — | — | EP | disclosed |
| US-4604399-A | 5-methyl(or ethyl)-1,6-naphthyridin-2(1H)-one 6-oxides, their preparation and the cardiotonic use thereof | STERLING DRUG INC. (US) | 1986-08-05 | — | — | US | disclosed |
| US-4559347-A | 3-Substituted-5-alkyl-1,6-naphthyridin-2(1H)-ones, cardiotonic use and preparation thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4532247-A | Increases cardiac contractility | STERLING DRUG INC. (US) | 1985-07-30 | — | — | US | disclosed |
| US-4524149-A | 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1985-06-18 | — | — | US | disclosed |
| US-4517190-A | 5-Alkyl-1,6-naphthyridin-2(1H)-ones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-14 | — | — | US | disclosed |
| EP-0134535-A1 | 1,6-Naphthyridin derivatives useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1985-03-20 | — | — | EP | disclosed |
| EP-0101952-A1 | 5-Alkyl-1,6-naphthyridin-2(1H)-ones, intermediates, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1984-03-07 | — | — | EP | disclosed |
| US-4415580-A | Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same | STERLING DRUG INC. (US) | 1983-11-15 | — | — | US | disclosed |
| US-4412077-A | Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone | STERLING DRUG INC. (US) | 1983-10-25 | — | — | US | disclosed |
| EP-0089022-A2 | Alkanoylpyridinones useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1983-09-21 | — | — | EP | disclosed |