Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.64 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.58 |
| ▸ | BCL2 | P10415 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.55 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307616 | 0.91 | CYP1A1 (0.58) | DYRK1ADYRK1BKDM4ECYP1A1CYP1A2 | |
| SCHEMBL8574988 | 0.86 | DYRK1A (0.50) | DYRK1ADYRK1BMEN1ALDH1A1POLB | |
| SCHEMBL7380087 | 0.85 | CSNK2A2 (0.67) | MEN1ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL20045159 | 0.84 | DYRK1A (0.84) | DYRK1ADYRK1BMEN1ALDH1A1POLB | |
| SCHEMBL8429610 | 0.84 | DYRK1A (0.48) | DYRK1ADYRK1BMEN1ALDH1A1POLB | |
| SCHEMBL8305241 | 0.82 | KDM4E (0.52) | DYRK1ADYRK1BKDM4ECYP1A1CYP1A2 | |
| SCHEMBL3173373 | 0.81 | CYP1B1 (0.54) | DYRK1ADYRK1BMEN1ALDH1A1POLB | |
| SCHEMBL30954258 | 0.81 | MEN1 (0.71) | MEN1ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL8305238 | 0.79 | AKT1 (0.52) | DYRK1ADYRK1BBCL2AKT1 | |
| SCHEMBL3192344 | 0.79 | DYRK1A (0.51) | DYRK1ADYRK1BMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115718-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017184-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-03-30 | — | — | WO | disclosed |